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17 May 2013
Arthroblog No 2 Scleroderma
Scleroderma, also known as systemic
sclerosis, is a rare connective tissue disorder that typically affects women
between the ages of 30 and 60. Though the term scleroderma (from the Greek for
"hard skin") was coined by Giovanni Batista Fantonetti (1791-1861) in the 1830s,
the disease has far earlier origins. The initial case description may have been
made by Hippocrates in the early 4th century BCE, when he described a man with
general itching and thick skin. The first modern description was published by Dr
Carlo Curzio in 1753. Despite its long and varied history, surprisingly little
is known about either the underlying causes or the factors that regulate disease
progression. There was little interest in this disease again until the mid-late
1900s. Now it is a clearly defined disease with extensive and ongoing research
into its pathophysiology and treatment options.