17 May 2013

Arthroblog No 2 Scleroderma

Wendy Smith
Scleroderma, also known as systemic sclerosis, is a rare connective tissue disorder that typically affects women between the ages of 30 and 60. Though the term scleroderma (from the Greek for "hard skin") was coined by Giovanni Batista Fantonetti (1791-1861) in the 1830s, the disease has far earlier origins. The initial case description may have been made by Hippocrates in the early 4th century BCE, when he described a man with general itching and thick skin. The first modern description was published by Dr Carlo Curzio in 1753. Despite its long and varied history, surprisingly little is known about either the underlying causes or the factors that regulate disease progression. There was little interest in this disease again until the mid-late 1900s. Now it is a clearly defined disease with extensive and ongoing research into its pathophysiology and treatment options.

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